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UCD 2D-PAGE [All]

Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland


UCD 2D-PAGE 
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Searching in 'UCD 2D-PAGE [All]' for entry matching: P02675




UCD 2D-PAGE (UCD 2D-PAGE):  P02675


P02675


General information about the entry
View entry in simple text format
Entry nameFIBB_HUMAN
Primary accession numberP02675
integrated into UCD 2D-PAGE (UCD 2D-PAGE) on November 23, 2015 (release 1)
2D Annotations were last modified onNovember 23, 2015 (version 1)
General Annotations were last modified on January 7, 2016 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Fibrinogen beta chain; Contains: RecName: Full=Fibrinopeptide B; Contains: RecName: Full=Fibrinogen beta chain; Flags: Precursor;.
Gene nameName=FGB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   CHARACTERISATION
PubMed=21751342; [NCBI, EBI, Israel, Japan]
Polden J., McManus CA., Dos Remedios C., Dunn MJ.
''A 2-D gel reference map of the basic human heart proteome''
Proteomics 11(17):3582-3586 (2011)
[2]   CHARACTERISATION
PubMed=19562803; [NCBI, EBI, Israel, Japan]
English JA., Dicker P., Focking M., Cotter DR.
''2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease''
Proteomics 9(12):3368-3382 (2009)
[3]   CHARACTERISATION
PubMed=20432482; [NCBI, EBI, Israel, Japan]
McManus CA., Polden J., Cotter DR., Dunn MJ.
''Two-dimensional reference map for the basic proteome of the human dorsolateral prefrontal cortex (dlPFC) of the prefrontal lobe region of the brain''
Proteomics 10(13):2551-2555 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

BRAIN_DLPFC_6-11 {Human Brain DLPFC pH 6-11}
Homo sapiens (Human)
Tissue: Brain cortex
BRAIN_DLPFC_6-11
  map experimental info
 
BRAIN_DLPFC_6-11

MAP LOCATIONS:
pI=6.02; Mw=56430  [identification data]
pI=6.14; Mw=54330  [identification data]

% AA COVERAGE: SPOT 455: 11%
SPOT 459: 3%.
INSTRUMENT: SPOT 455: FT-LTQ
SPOT 459: FT-LTQ.
MASCOT SCORE: SPOT 455: 82
SPOT 459: 70.
THEORETICAL MW: SPOT 455: 56000
SPOT 459: 56000.
THEORETICAL PI: SPOT 455: 8.5
SPOT 459: 8.5.
UNIQUE PEPTIDES: SPOT 455: 3
SPOT 459: 1.
MAPPING (identification):
SPOT 455: Tandem mass spectrometry;
SPOT 459: Tandem mass spectrometry.



BRAIN-DLPFC-WHITE-MATTER {Dorsolateral Pre Frontal Cortex White Matter Human Post Mortem Brain, pH 4-7}
Sus scrofa (Pig)
Tissue: Brain cortex
BRAIN-DLPFC-WHITE-MATTER
  map experimental info
 
BRAIN-DLPFC-WHITE-MATTER

MAP LOCATIONS:
pI=5.80; Mw=48000  [identification data]
pI=4.20; Mw=30000  [identification data]

EXPRESSION:
SPOT 1032: Fold change in schizophrenia: 1.404 and fold change in bipolar disorder: 1.384;
SPOT 1424: Fold change in schizophrenia: -1.215 and fold change in bipolar disorder: -1.277.

FUNCTIONAL ONTOLOGY: SPOT 1032: Protein Metabolism
SPOT 1424: Protein Metabolism.
GENE MAP LOCUS: SPOT 1032: 4q28
SPOT 1424: 4q28.
THEORETICAL MW: SPOT 1032: 55.928
SPOT 1424: 55.928.
THEORETICAL PI: SPOT 1032: 4.14
SPOT 1424: 4.14.
MAPPING (identification):
SPOT 1032: Tandem mass spectrometry;
SPOT 1424: Tandem mass spectrometry.



HEART_PH6-11_BRIDGE {Whole human heart, pH 6-11 IPG, bridge loading}
Homo sapiens (Human)
Tissue: Heart ventricle
HEART_PH6-11_BRIDGE
  map experimental info
 
HEART_PH6-11_BRIDGE

MAP LOCATIONS:
pI=6.65; Mw=53470  [identification data]

% AA COVERAGE: SPOT 267: 31.4.
INSTRUMENT: SPOT 267: Orbitrap.
MASCOT SCORE: SPOT 267: 229.
THEORETICAL MW: SPOT 267: 50762.
THEORETICAL PI: SPOT 267: 7.95.
UNIQUE PEPTIDES: SPOT 267: 12.
MAPPING (identification):
SPOT 267: Tandem mass spectrometry.

Cross-references
UniProtKB/Swiss-ProtP02675; FIBB_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameFIBB_HUMAN
Primary accession numberP02675
Secondary accession number(s) A0JLR9 B2R7G3 Q32Q65 Q3KPF2
Sequence was last modified on July 1, 1993 (version 2)
Annotations were last modified on December 9, 2015 (version 193)
Name and origin of the protein
DescriptionRecName: Full=Fibrinogen beta chain; Contains: RecName: Full=Fibrinopeptide B; Contains: RecName: Full=Fibrinogen beta chain; Flags: Precursor;
Gene nameName=FGB
Encoded onName=FGB
Keywords3D-structure; Adaptive immunity; Blood coagulation; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Immunity; Innate immunity; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLJ00129; AAA52429.1; -; mRNA
EMBLJ00131; AAA98115.1; -; Genomic_DNA
EMBLJ00130; AAA98115.1; JOINED; Genomic_DNA
EMBLJ00132; AAA98116.1; -; Genomic_DNA
EMBLJ00133; -; NOT_ANNOTATED_CDS; mRNA
EMBLM64983; AAA18024.2; -; Genomic_DNA
EMBLAF388026; AAK62470.1; -; Genomic_DNA
EMBLAK312972; BAG35810.1; -; mRNA
EMBLCH471056; EAX04932.1; -; Genomic_DNA
EMBLBC007030; AAH07030.1; ALT_SEQ; mRNA
EMBLBC106760; AAI06761.1; -; mRNA
EMBLBC107766; AAI07767.1; -; mRNA
EMBLAH002694; AAA52445.1; -; Genomic_DNA
EMBLX05018; CAA28674.1; -; Genomic_DNA
CCDSCCDS3786.1; -; .
PIRB43568; FGHUB; .
RefSeqNP_001171670.1; NM_001184741.1; .
RefSeqNP_005132.2; NM_005141.4; .
UniGeneHs.300774; -; .
PDB1FZA; X-ray; 2.90 A; B/E=164-491
PDB1FZB; X-ray; 2.90 A; B/E=164-491
PDB1FZC; X-ray; 2.30 A; B/E=164-491
PDB1FZE; X-ray; 3.00 A; B/E=164-491
PDB1FZF; X-ray; 2.70 A; B/E=164-491
M/N/S/T=45-48PDB; 1FZG; X-ray; 2.50 A
B/E=164-491PDB; 1LT9; X-ray; 2.80 A
B/E=179-491PDB; 1LTJ; X-ray; 2.80 A
B/E=179-491PDB; 1N86; X-ray; 3.20 A
B/E=164-491I/J=45-51; PDB; 1N8E; X-ray
4.50 AB/E=164-491; PDB; 1RE3; X-ray
2.45 AB/E=179-491; PDB; 1RE4; X-ray
2.70 AB/E=179-491; PDB; 1RF0; X-ray
2.81 AB/E=179-491; PDB; 1RF1; X-ray
2.53 AB/E=179-491; PDB; 2A45; X-ray
3.65 AH/K=45-135; PDB; 2FFD; X-ray
2.89 AB/E=179-491; PDB; 2H43; X-ray
2.70 AB/E=164-491; PDB; 2HLO; X-ray
2.60 AB/E=164-491; PDB; 2HOD; X-ray
2.90 AB/E/H/K=164-491; PDB; 2HPC; X-ray
2.90 AB/E/H/K=164-491; PDB; 2OYH; X-ray
2.40 AB/E=179-491; PDB; 2OYI; X-ray
2.70 AB/E=179-491; PDB; 2Q9I; X-ray
2.80 AB/E=164-491; PDB; 2XNX; X-ray
3.30 AB/E/H/K=164-491; PDB; 2XNY; X-ray
7.50 AB/E=164-491; PDB; 2Z4E; X-ray
2.70 AB/E=164-489; PDB; 3BVH; X-ray
2.60 AB/E=191-488; PDB; 3E1I; X-ray
2.30 AB/E=164-491; PDB; 3GHG; X-ray
2.90 AB/E/H/K=31-491; PDB; 3H32; X-ray
3.60 AB/E=31-488; PDB; 3HUS; X-ray
3.04 AB/E=179-491; PDBsum; 1FZA; -
PDBsum1FZB; -; .
PDBsum1FZC; -; .
PDBsum1FZE; -; .
PDBsum1FZF; -; .
PDBsum1FZG; -; .
PDBsum1LT9; -; .
PDBsum1LTJ; -; .
PDBsum1N86; -; .
PDBsum1N8E; -; .
PDBsum1RE3; -; .
PDBsum1RE4; -; .
PDBsum1RF0; -; .
PDBsum1RF1; -; .
PDBsum2A45; -; .
PDBsum2FFD; -; .
PDBsum2H43; -; .
PDBsum2HLO; -; .
PDBsum2HOD; -; .
PDBsum2HPC; -; .
PDBsum2OYH; -; .
PDBsum2OYI; -; .
PDBsum2Q9I; -; .
PDBsum2XNX; -; .
PDBsum2XNY; -; .
PDBsum2Z4E; -; .
PDBsum3BVH; -; .
PDBsum3E1I; -; .
PDBsum3GHG; -; .
PDBsum3H32; -; .
PDBsum3HUS; -; .
ProteinModelPortalP02675; -; .
SMRP02675; 88-488; .
BioGrid108535; 111; .
DIPDIP-385N; -; .
IntActP02675; 16; .
STRING9606.ENSP00000306099; -; .
BindingDBP02675; -; .
ChEMBLCHEMBL2364709; -; .
DrugBankDB00364; Sucralfate; .
PhosphoSiteP02675; -; .
BioMutaFGB; -; .
DMDM399492; -; .
DOSAC-COBS-2DPAGEP02675; -; .
OGPP02675; -; .
REPRODUCTION-2DPAGEIPI00298497; -; .
REPRODUCTION-2DPAGEP02675; -; .
SWISS-2DPAGEP02675; -; .
UCD-2DPAGEP02675; -; .
PaxDbP02675; -; .
PeptideAtlasP02675; -; .
PRIDEP02675; -; .
EnsemblENST00000302068; ENSP00000306099; ENSG00000171564; .
GeneID2244; -; .
KEGGhsa:2244; -; .
UCSCuc003ioa.4; human; .
CTD2244; -; .
GeneCardsFGB; -; .
HGNCHGNC:3662; FGB; .
HPACAB008624; -; .
HPAHPA001900; -; .
HPAHPA001901; -; .
MalaCardsFGB; -; .
MIM134830; gene; .
MIM202400; phenotype; .
MIM616004; phenotype; .
neXtProtNX_P02675; -; .
Orphanet98880; Familial afibrinogenemia; .
Orphanet98881; Familial dysfibrinogenemia; .
Orphanet248408; Familial hypodysfibrinogenemia; .
Orphanet101041; Familial hypofibrinogenemia; .
PharmGKBPA163; -; .
eggNOGKOG2579; Eukaryota; .
eggNOGENOG410ZYS4; LUCA; .
HOGENOMHOG000059561; -; .
HOVERGENHBG005707; -; .
InParanoidP02675; -; .
KOK03904; -; .
OMATIHNGMF; -; .
OrthoDBEOG7X9G60; -; .
PhylomeDBP02675; -; .
TreeFamTF336658; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
ReactomeR-HSA-140875; Common Pathway of Fibrin Clot Formation; .
ReactomeR-HSA-216083; Integrin cell surface interactions; .
ReactomeR-HSA-354192; Integrin alphaIIb beta3 signaling; .
ReactomeR-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; .
ReactomeR-HSA-372708; p130Cas linkage to MAPK signaling for integrins; .
ReactomeR-HSA-5674135; MAP2K and MAPK activation; .
ChiTaRSFGB; human; .
EvolutionaryTraceP02675; -; .
GeneWikiFibrinogen_beta_chain; -; .
GenomeRNAi2244; -; .
NextBio35459926; -; .
PMAP-CutDBP02675; -; .
PROPR:P02675; -; .
ProteomesUP000005640; Chromosome 4; .
BgeeP02675; -; .
CleanExHS_FGB; -; .
ExpressionAtlasP02675; baseline and differential; .
GenevisibleP02675; HS; .
GOGO:0072562; C:blood microparticle; IDA:UniProtKB; .
GOGO:0005938; C:cell cortex; IEA:Ensembl; .
GOGO:0009986; C:cell surface; IDA:BHF-UCL; .
GOGO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005576; C:extracellular region; NAS:UniProtKB; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:1903561; C:extracellular vesicle; IDA:UniProtKB; .
GOGO:0005577; C:fibrinogen complex; IDA:UniProtKB; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0031091; C:platelet alpha granule; IDA:BHF-UCL; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0051087; F:chaperone binding; IPI:BHF-UCL; .
GOGO:0005198; F:structural molecule activity; IDA:BHF-UCL; .
GOGO:0002250; P:adaptive immune response; IEA:UniProtKB-KW; .
GOGO:0007596; P:blood coagulation; TAS:Reactome; .
GOGO:0072378; P:blood coagulation; fibrin clot formation; IDA:UniProtKB
GOGO:0007160; P:cell-matrix adhesion; IDA:BHF-UCL; .
GOGO:0043623; P:cellular protein complex assembly; IDA:BHF-UCL; .
GOGO:0071347; P:cellular response to interleukin-1; IEA:Ensembl; .
GOGO:0044320; P:cellular response to leptin stimulus; IEA:Ensembl; .
GOGO:0030198; P:extracellular matrix organization; TAS:Reactome; .
GOGO:0042730; P:fibrinolysis; IDA:UniProtKB; .
GOGO:0043152; P:induction of bacterial agglutination; IDA:CACAO; .
GOGO:0045087; P:innate immune response; IEA:UniProtKB-KW; .
GOGO:2000352; P:negative regulation of endothelial cell apoptotic process; IDA:BHF-UCL; .
GOGO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL; .
GOGO:0031639; P:plasminogen activation; IDA:UniProtKB; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0070527; P:platelet aggregation; IDA:BHF-UCL; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; .
GOGO:0045921; P:positive regulation of exocytosis; IDA:BHF-UCL; .
GOGO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL; .
GOGO:0090277; P:positive regulation of peptide hormone secretion; IDA:BHF-UCL; .
GOGO:0050714; P:positive regulation of protein secretion; IDA:BHF-UCL; .
GOGO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; NAS:BHF-UCL; .
GOGO:0045907; P:positive regulation of vasoconstriction; IDA:BHF-UCL; .
GOGO:0051258; P:protein polymerization; IDA:BHF-UCL; .
GOGO:0051592; P:response to calcium ion; IDA:BHF-UCL; .
GOGO:0007165; P:signal transduction; IEA:InterPro; .
Gene3D3.90.215.10; -; 1; .
Gene3D4.10.530.10; -; 1; .
InterProIPR014716; Fibrinogen_a/b/g_C_1; .
InterProIPR014715; Fibrinogen_a/b/g_C_2; .
InterProIPR002181; Fibrinogen_a/b/g_C_dom; .
InterProIPR012290; Fibrinogen_a/b/g_coil_dom; .
InterProIPR020837; Fibrinogen_CS; .
PfamPF08702; Fib_alpha; 1; .
PfamPF00147; Fibrinogen_C; 1; .
SMARTSM00186; FBG; 1; .
SUPFAMSSF56496; SSF56496; 1; .
PROSITEPS00514; FIBRINOGEN_C_1; 1; .
PROSITEPS51406; FIBRINOGEN_C_2; 1; .



UCD 2D-PAGE image


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Database constructed using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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